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Influence of Autonomic Nervous Dysfunction Characterizing Effect of Diabetes Mellitus on Heart Rate Response and Exercise Capacity in Patients Undergoing Cardiac Rehabilitation for Acute Myocardial Infarction
- Source :
- Circulation Journal. 70:1017-1025
- Publication Year :
- 2006
- Publisher :
- Japanese Circulation Society, 2006.
-
Abstract
- Background The aim of this study was to clarify the influence of sympathetic and parasympathetic nerve (SN and PN) dysfunction on the heart rate (HR) response to exercise and the exercise capacity of patients with acute myocardial infarction (AMI) and diabetes mellitus (DM). Methods and Results Fifty-two male patients who underwent cardiopulmonary exercise testing (CPX) 1 month after onset of AMI were divided into 2 groups: (DM (+) group, n=20; DM (-) group, n=32). HR, peak oxygen uptake (VO2peak), and plasma norepinephrine (NE) levels were measured during CPX. The high-frequency power (HF) was analyzed by HR variability. The ΔHR/log ΔNE obtained from changes of HR and NE from rest to peak exercise and HR change from baseline to the minimum HF (ΔHRHF) were calculated as parameters of HR response derived from SN and PN activities, respectively. ΔHR, VO2peak, ΔHR/log ΔNE, and ΔHRHF were significantly lower in the DM (+) group than in the DM (-) group, and both of them showed positive correlations with VO2peak. Conclusion An inadequate HR response to exercise is a major factor causing a decline of exercise capacity, which is derived from both of SN and PN dysfunction, in AMI patients with DM. (Circ J 2006; 70: 1017 - 1025)
- Subjects :
- Male
medicine.medical_specialty
Sympathetic Nervous System
medicine.medical_treatment
Myocardial Infarction
Autonomic Nervous System
Norepinephrine
Oxygen Consumption
Diabetic Neuropathies
Heart Rate
Parasympathetic Nervous System
Internal medicine
Diabetes mellitus
Heart rate
Diabetes Mellitus
medicine
Humans
In patient
Myocardial infarction
Exercise Tolerance
Rehabilitation
business.industry
VO2 max
General Medicine
Middle Aged
Exercise capacity
medicine.disease
Autonomic nervous system
Case-Control Studies
Data Interpretation, Statistical
Exercise Test
Physical therapy
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....a6961238f5b3834d6f333d6389f89a73