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Leucine-rich alpha-2 glycoprotein 1, high mobility group box 1, matrix metalloproteinase 3 and annexin A1 as biomarkers of ulcerative colitis endoscopic and histological activity
- Source :
- European Journal of Gastroenterology & Hepatology. 32:1106-1115
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Objective The LRG, HMGB1, MMP3 and ANXA1 proteins have been implicated in different inflammatory pathways in ulcerative colitis (UC), but their role as specific biomarkers of both endoscopic and histological activity has yet to be elucidated. In the present study, we aimed to evaluate the LRG1, HMGB1, MMP3 and ANXA1 as potential serum biomarkers for UC endoscopic and histological activity. Methods This cross-sectional study included UC patients under 5-ASA, and healthy controls (HC) undergoing colonoscopy. Blood and biopsy samples were obtained and endoscopic Mayo sub-score (Ms) was recorded for the UC patients. Intramucosal calprotectin as a marker of histologic activity was evaluated in all biopsy samples and serum LRG1, HMGB1, MMP3 and ANXA1 levels were measured in the blood samples. Results The HCs ANXA1 level was lower compared to that of the UC group [P = 0.00, area under the curve (AUC) = 0.881] and so was the HCs MMP3 level compared to that of patients (P = 0.00, AUC = 0.835). The HCs ANXA1 levels were also lower compared to these of the independent Ms groups, even to the Ms = 0 (P = 0.00, AUC = 0.913). UC endoscopic activity was associated with MMP3 levels (r = 0.54, P = 0.000) but not with ANXA1, LRG1 and HMGB1 levels CONCLUSION: Serum ANXA1 is a potential diagnostic biomarker of UC and serum MMP3 is a potential biomarker of UC endoscopic and histological activity.
- Subjects :
- endocrine system
medicine.medical_specialty
MMP3
Colonoscopy
Severity of Illness Index
Gastroenterology
Feces
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biopsy
Humans
Medicine
HMGB1 Protein
Intestinal Mucosa
Annexin A1
Glycoproteins
Hepatology
medicine.diagnostic_test
business.industry
Area under the curve
medicine.disease
Ulcerative colitis
body regions
Cross-Sectional Studies
LRG1
030220 oncology & carcinogenesis
Colitis, Ulcerative
Matrix Metalloproteinase 3
030211 gastroenterology & hepatology
Calprotectin
business
Leukocyte L1 Antigen Complex
Biomarkers
Subjects
Details
- ISSN :
- 0954691X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- European Journal of Gastroenterology & Hepatology
- Accession number :
- edsair.doi.dedup.....a68cb6ac88715529095e5ce2590ec9b0