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Clinical features and outcomes of 1845 patients with follicular lymphoma: a real-world multicenter experience in China
- Source :
- Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021), Journal of Hematology & Oncology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Clinical features and outcomes of FL patients in Chinese population are limited, thus promoting us to perform this analysis on a large cohort of 1845 patients with FL enrolled from nine medical centers nationwide in China. In this cohort, the median age of patients at diagnosis was 53 years, which was comparable to that reported previously for Chinese FL patients (49–51 years) but younger than that for Western FL patients (60–65 years). In contrast with Western patients, Chinese FL patients more likely involved extranodal sites but less frequently infiltrated bone marrow. Other clinical characteristics were comparable between two populations. In this study, 91% of patients were managed with chemotherapy, yielding 72% and 46% of overall-response rate and complete remission. After median 55-month follow-up, 5-year progressive-free and overall survival were 61% and 89%, respectively. Both were analogous to those reported in prior Chinese and Western studies. Consistent with published data, addition of rituximab into both induction (Ri) and maintenance (Rm) treatment led to the most favorable outcomes. Interestingly, Ri only had better outcomes than Rm only. Notably, 7% of patients experienced histologic transformation (HT) and correlated with poor survival. Of the transformed FL cases, 3% and 4% of HT events occurred prior to or post-treatment, respectively. Importantly, the latter displayed worse outcomes than the former. Altogether, this study provides real-world information of the largest cohort of FL patients so far in China, which might lay a foundation for clinical investigation of Chinese FL in future.
- Subjects :
- Male
China
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Follicular lymphoma
Cohort Studies
Antineoplastic Agents, Immunological
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Chemotherapy
Diseases of the blood and blood-forming organs
Histological transformation (HT)
Letter to the Editor
Cyclophosphamide
Lymphoma, Follicular
Molecular Biology
RC254-282
Aged
Follicular lymphoma (FL)
Chinese
Hematology
business.industry
Complete remission
Disease Management
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Middle Aged
medicine.disease
Survival Analysis
medicine.anatomical_structure
Oncology
Doxorubicin
Vincristine
Cohort
Prednisone
Female
Rituximab
Bone marrow
RC633-647.5
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 17568722
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Hematology & Oncology
- Accession number :
- edsair.doi.dedup.....a68c62150548ed6a7e31e7120d4e1c70