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EFFECT OF RENAL NERVE DENERVATION ON TISSUE CATECHOLAMINE CONTENT IN SPONTANEOUSLY HYPERTENSIVE RATS

Authors :
Makoto Yoshida
Emiko Yoshida
Susumu Satoh
Source :
Clinical and Experimental Pharmacology and Physiology. 22:512-517
Publication Year :
1995
Publisher :
Wiley, 1995.

Abstract

1. To clarify the possible role of tissue catecholamines in the development of hypertension, we investigated the effect of bilateral renal denervation on the catecholamine contents of central and peripheral tissues in spontaneously hypertensive rats (SHR). 2. Norepinephrine (NE) content in renal cortex, renal medulla, and adrenal gland was higher in 7 week old SHR than age-matched Wistar-Kyoto rats (WKY). Dopamine (DA) content in the brainstem and hypothalamus was also higher in SHR, but NE and epinephrine (EPI) content in these areas were not different between strains. Similar differences in catecholamines were observed in 9 week old rats in which a sham operation of bilateral renal denervation was performed 2 weeks previously. 3. Bilateral renal denervation produced an almost complete reduction of NE content in the kidney in both strains and prevented the development of hypertension. DA content in the brainstem was also decreased by renal denervation in SHR but not in WKY. NE and EPI content in central tissues were not affected by renal denervation. 4. These results suggest that DA content in brainstem area, as well as NE content in the kidney, have a relationship in the development of hypertension in SHR.

Details

ISSN :
14401681 and 03051870
Volume :
22
Database :
OpenAIRE
Journal :
Clinical and Experimental Pharmacology and Physiology
Accession number :
edsair.doi.dedup.....a67fab97d8a1d24a7bca70eac21b7abe
Full Text :
https://doi.org/10.1111/j.1440-1681.1995.tb02059.x