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EFFECT OF RENAL NERVE DENERVATION ON TISSUE CATECHOLAMINE CONTENT IN SPONTANEOUSLY HYPERTENSIVE RATS
- Source :
- Clinical and Experimental Pharmacology and Physiology. 22:512-517
- Publication Year :
- 1995
- Publisher :
- Wiley, 1995.
-
Abstract
- 1. To clarify the possible role of tissue catecholamines in the development of hypertension, we investigated the effect of bilateral renal denervation on the catecholamine contents of central and peripheral tissues in spontaneously hypertensive rats (SHR). 2. Norepinephrine (NE) content in renal cortex, renal medulla, and adrenal gland was higher in 7 week old SHR than age-matched Wistar-Kyoto rats (WKY). Dopamine (DA) content in the brainstem and hypothalamus was also higher in SHR, but NE and epinephrine (EPI) content in these areas were not different between strains. Similar differences in catecholamines were observed in 9 week old rats in which a sham operation of bilateral renal denervation was performed 2 weeks previously. 3. Bilateral renal denervation produced an almost complete reduction of NE content in the kidney in both strains and prevented the development of hypertension. DA content in the brainstem was also decreased by renal denervation in SHR but not in WKY. NE and EPI content in central tissues were not affected by renal denervation. 4. These results suggest that DA content in brainstem area, as well as NE content in the kidney, have a relationship in the development of hypertension in SHR.
- Subjects :
- medicine.medical_specialty
Epinephrine
Physiology
Dopamine
Renal cortex
Blood Pressure
Kidney
Rats, Inbred WKY
Norepinephrine
Catecholamines
Heart Rate
Rats, Inbred SHR
Physiology (medical)
Internal medicine
Renal medulla
Animals
Medicine
Pharmacology
Denervation
business.industry
Adrenal gland
Body Weight
Rats
medicine.anatomical_structure
Endocrinology
Renal physiology
Hypertension
Catecholamine
business
medicine.drug
Subjects
Details
- ISSN :
- 14401681 and 03051870
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Pharmacology and Physiology
- Accession number :
- edsair.doi.dedup.....a67fab97d8a1d24a7bca70eac21b7abe
- Full Text :
- https://doi.org/10.1111/j.1440-1681.1995.tb02059.x