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The Effects of Burn Injury on the Acute Phase Response
- Source :
- The Journal of Trauma: Injury, Infection, and Critical Care. 32:236-251
- Publication Year :
- 1992
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1992.
-
Abstract
- The time course of changes in the levels of acute-phase-reactant (APR) mRNAs in different tissues of rats with a 10% or a 60% total-body-surface-area (TBSA) burn and the relationship between the induction of APRs and the host's tolerance to thermal injury were studied. The acute phase response in a LPS-induced inflammation model and a burn-plus-LPS model were compared. The results of this study indicated that (1) the major site of APR synthesis is the liver; (2) even a small surface burn injury can elicit a rapid acute phase response, but the intensity of APR expression increases with the severity of the burn; (3) the down regulation of albumin mRNA, which is characteristic of the acute phase response, does not occur even though transferrin (Trf) mRNA levels are significantly decreased; (4) the resistant strain of inbred rats showed higher levels of alpha 1-antitrypsin (AT) mRNA before and after burn injury, indicating its contribution to the host's tolerance to thermal injury; (5) the increases in alpha 1-acid glycoprotein (AGP) and AT expressions are limited in the burn-plus-LPS rat model compared with either the burn model or LPS-stimulated model alone.
- Subjects :
- Lipopolysaccharides
Male
Pathology
medicine.medical_specialty
Burn injury
Gene Expression
Alpha (ethology)
Poison control
Inflammation
Critical Care and Intensive Care Medicine
Albumins
Internal medicine
medicine
Animals
RNA, Messenger
Rats, Inbred BUF
chemistry.chemical_classification
Thermal injury
business.industry
Transferrin
Albumin
Acute-phase protein
Rats, Inbred Strains
Orosomucoid
Rats, Inbred F344
Rats
Endocrinology
Liver
chemistry
alpha 1-Antitrypsin
Pseudomonas aeruginosa
Surgery
medicine.symptom
Burns
business
Acute-Phase Proteins
Subjects
Details
- ISSN :
- 00225282
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- The Journal of Trauma: Injury, Infection, and Critical Care
- Accession number :
- edsair.doi.dedup.....a67c426a63187fc69a44c49a30db16a1