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Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children
- Source :
- Vaccine. 18(1-2)
- Publication Year :
- 1999
-
Abstract
- Intranasal trivalent, cold-adapted, live attenuated influenza vaccine (CAIV-T) is a promising alternative to inactivated vaccine for protection against influenza in children. However, correlates of immunity are not well defined. To determine the mucosal immune response to CAIV-T, 19 children ages 15-55 months were randomized to receive two doses of CAIV-T or placebo. Influenza-specific IgA to the haemagglutinin of each of three contemporary strains was measured in nasal washes collected pre- and postvaccination using a kinetic enzyme-linked immunosorbent assay. After two doses of study drug, 62, 69 and 85% of CAIV-T recipients demonstrated a mucosal IgA response to influenza A/H1N1, A/H3N2, and B strains respectively; in comparison, 33, 0 and 17% of placebo recipients demonstrated an IgA response to the same strains (p = 0.35, 0.01 and 0.01). Overall, seropositive vaccinees were 4.5 times more likely to develop a mucosal immune response than an HAI response (p = 0.015). Two doses of CAIV-T induce a mucosal IgA response to all three influenza vaccine antigens in the majority of children. In addition, a mucosal antibody response may be the only indication of a vaccine take in a seropositive child.
- Subjects :
- Immunoglobulin A
Influenza vaccine
Orthomyxoviridae
Enzyme-Linked Immunosorbent Assay
Antibodies, Viral
Vaccines, Attenuated
Sensitivity and Specificity
Antigen
Immunity
Live attenuated influenza vaccine
Medicine
Humans
Immunity, Mucosal
Administration, Intranasal
General Veterinary
General Immunology and Microbiology
biology
business.industry
Influenzavirus B
Public Health, Environmental and Occupational Health
virus diseases
Infant
Hemagglutination Inhibition Tests
biology.organism_classification
Virology
Infectious Diseases
Influenza Vaccines
Child, Preschool
Inactivated vaccine
Immunology
Immunoglobulin A, Secretory
biology.protein
Molecular Medicine
business
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 18
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....a66d0f7e98d64e149b0beebcaa678872