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sICAM-1, sCD95 and sCD95L levels in chronic liver diseases of different etiology
- Source :
- Scopus-Elsevier
-
Abstract
- The release of soluble circulating molecules represents a prominent feature during the course of immune-mediated clinical conditions. To further assess the relationship between serum concentrations of adhesion or apoptotic-related soluble structures and liver diseases, we evaluated the levels of intercellular adhesion molecule-1 (sICAM-1), Fas receptor (CD95) and Fas ligand (sCD95L) in a group of patients affected by Hepatitis C Virus (HCV)-induced chronic hepatitis (CH-C), HCV-positive liver cirrhosis with superimposed hepatocellular carcinoma (HCC), autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and alcoholic liver cirrhosis (ALC). Results show that sICAM-1 values were in all instances significantly elevated when compared to those seen in healthy donors. Similar findings were noted in subjects with liver diseases in terms of sCD95 concentrations, even if to a different degree of statistical significance. Finally, sCD95L amounts were augmented in AIH, PBC, ALC and CH-C in comparison to controls, while in the HCC counterpart sCD95L levels fell within normal range. All together, these findings emphasize the occurrence of circulating soluble molecules in patients with various chronic liver diseases, likely reflecting the involvement of several pathogenetic mechanisms.
- Subjects :
- Adult
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Cirrhosis
Hepatitis C virus
Immunology
Autoimmune hepatitis
Toxicology
medicine.disease_cause
Gastroenterology
Primary biliary cirrhosis
Liver Cirrhosis, Alcoholic
Internal medicine
medicine
Humans
Immunology and Allergy
fas Receptor
Aged
Hepatitis, Chronic
Pharmacology
medicine.diagnostic_test
Liver Cirrhosis, Biliary
business.industry
Liver Diseases
General Medicine
Hepatitis C
Hepatitis C, Chronic
Middle Aged
Intercellular Adhesion Molecule-1
Fas receptor
medicine.disease
digestive system diseases
Hepatitis, Autoimmune
Hepatocellular carcinoma
Female
business
Liver function tests
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....a6683b3d6a485d244a4195230cd5a5f8