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Acupuncture for Parkinson’s Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit
- Source :
- Neural Plasticity, Neural Plasticity, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease caused by degeneration of dopaminergic neurons in the substantia nigra. Existing pharmaceutical treatments offer alleviation of symptoms but cannot delay disease progression and are often associated with significant side effects. Clinical studies have demonstrated that acupuncture may be beneficial for PD treatment, particularly in terms of ameliorating PD symptoms when combined with anti-PD medication, reducing the required dose of medication and associated side effects. During early stages of PD, acupuncture may even be used to replace medication. It has also been found that acupuncture can protect dopaminergic neurons from degeneration via antioxidative stress, anti-inflammatory, and antiapoptotic pathways as well as modulating the neurotransmitter balance in the basal ganglia circuit. Here, we review current studies and reflect on the potential of acupuncture as a novel and effective treatment strategy for PD. We found that particularly during the early stages, acupuncture may reduce neurodegeneration of dopaminergic neurons and regulate the balance of the dopaminergic circuit, thus delaying the progression of the disease. The benefits of acupuncture will need to be further verified through basic and clinical studies.
- Subjects :
- Parkinson's disease
Dopamine
Acupuncture Therapy
Neurosciences. Biological psychiatry. Neuropsychiatry
Apoptosis
Substantia nigra
Review Article
Disease
Protein Aggregation, Pathological
Basal Ganglia
Antiparkinson Agents
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Basal ganglia
medicine
Acupuncture
Humans
Neurotransmitter
030304 developmental biology
Clinical Trials as Topic
0303 health sciences
business.industry
Dopaminergic Neurons
Neurodegeneration
Dopaminergic
Parkinson Disease
medicine.disease
Combined Modality Therapy
Oxidative Stress
Treatment Outcome
Neurology
chemistry
Bibliometrics
Neuroinflammatory Diseases
alpha-Synuclein
Neurology (clinical)
Nerve Net
business
Neuroscience
030217 neurology & neurosurgery
RC321-571
Subjects
Details
- ISSN :
- 16875443 and 20905904
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Neural Plasticity
- Accession number :
- edsair.doi.dedup.....a65c5ae4a492b16e67c50cd830e33661