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AN69 Filter Membranes with High Ultrafiltration Rates during Continuous Venovenous Hemofiltration Reduce Mortality in Patients with Sepsis-Induced Multiorgan Dysfunction Syndrome
- Source :
- Membranes, Volume 11, Issue 11, Membranes, Vol 11, Iss 837, p 837 (2021)
- Publication Year :
- 2021
-
Abstract
- Polyacrylonitrile (AN69) filter membranes adsorb cytokines during continuous venovenous hemofiltration (CVVH). Although high-volume hemofiltration has shown limited benefits, the dose-effect relationship in CVVH with AN69 membranes on severe sepsis remains undetermined. This multi-centered study enrolled 266 patients with sepsis-induced multiorgan dysfunction syndrome (MODS) who underwent CVVH with AN69 membranes between 2014 and 2015. We investigated the effects of ultrafiltration rates (UFR) on mortality. We categorized patients that were treated with UFR of 20–25 mL/kg/h as the standard UFR group (n = 124) and those that were treated with a UFR &gt<br />25 mL/kg/h as the high UFR group (n = 142). Among the patient characteristics, the baseline estimated glomerular filtration rates (eGFR) &lt<br />60 mL/min/1.73 m2, hemoglobin levels &lt<br />10 g/dL, and a sequential organ failure assessment (SOFA) score ≥15 at CVVH initiation were independently associated with in-hospital mortality. In the subgroup analysis, for patients with SOFA scores that were ≥15, the 90-day survival rate was higher in the high UFR group than in the standard UFR group (HR 0.54, CI: 0.36–0.79, p = 0.005). We concluded that in patients with sepsis-induced MODS, SOFA scores ≥15 predicted a poor rate of survival. High UFR setting &gt<br />25 mL/kg/h in CVVH with AN69 membranes may reduce the mortality risk in these high-risk patients.
- Subjects :
- medicine.medical_specialty
multiple organ failure
medicine.medical_treatment
Ultrafiltration
Urology
Renal function
Filtration and Separation
TP1-1185
intensive care unit
Article
law.invention
Sepsis
Chemical engineering
law
Hemofiltration
medicine
Chemical Engineering (miscellaneous)
business.industry
Chemical technology
Process Chemistry and Technology
Multiorgan dysfunction
blood purification
medicine.disease
Intensive care unit
Membrane
Continuous venovenous hemofiltration
critical medicine
TP155-156
business
Subjects
Details
- ISSN :
- 20770375
- Volume :
- 11
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Membranes
- Accession number :
- edsair.doi.dedup.....a65bad0a51d05582228e71eb7860bd22