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Incidence and characteristics of venous thromboembolism in Asian patients with primary central nervous system lymphoma undergoing chemotherapy
- Source :
- Thrombosis Research. 183:131-135
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Venous thromboembolism (VTE) may lead to diminished quality of life and ultimately worse prognosis in cancer patients, but there is limited data on the incidence, risk factors and mortality impact of VTE in Asian primary central nervous system lymphoma (PCNSL) patients.To report the incidence, risk factors and mortality impact of VTE in Asian PCNSL patients.From 7 academic centers in Korea, 235 newly diagnosed PCNSL patients undergoing chemotherapy were retrospectively identified during period of January 2004 to September 2018.All patients but 12 (6 T-cell, 6 other B-cell) had diffuse large B-cell lymphoma. During the median follow-up of 21 months, 33 patient (14.0%) developed VTE. Of the VTE events, 11 (33.3%) were deep vein thrombosis (DVT), 15 (45.5%) were pulmonary thromboembolism (PTE), and 7 (21.2%) were DVT with PTE. The median time to VTE was 2 months and the one-year actuarial incidence was 11.7%. On multivariate analysis, ECOG performance ≥2, age60 years, female sex, and Hb10 g/dL were independently associated with VTE. The patients with VTE were associated with shorter disease specific survival (P = 0.046) and overall survival (P = 0.022).Overall, the incidence of VTE in Asian PCNSL seems to be lower compared to Western population. As VTE development is associated with overall survival and indicative of relapse, careful close monitoring is warranted.
- Subjects :
- Adult
Male
medicine.medical_specialty
Lymphoma
Deep vein
Population
030204 cardiovascular system & hematology
Central Nervous System Neoplasms
Young Adult
03 medical and health sciences
0302 clinical medicine
Asian People
Quality of life
Internal medicine
Humans
Medicine
cardiovascular diseases
Risk factor
education
Aged
Retrospective Studies
Aged, 80 and over
education.field_of_study
business.industry
Incidence
Incidence (epidemiology)
Primary central nervous system lymphoma
Cancer
Venous Thromboembolism
Hematology
Middle Aged
equipment and supplies
medicine.disease
Thrombosis
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 183
- Database :
- OpenAIRE
- Journal :
- Thrombosis Research
- Accession number :
- edsair.doi.dedup.....a65902929016c9c2038665197c4df0e4