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Plasma carotenoids, tocopherols and retinol - Association with age in the Berlin Aging Study II
- Source :
- Redox Biology, Redox Biology, 32:101461, Redox Biology, Vol 32, Iss, Pp-(2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Regular consumption of fruits and vegetables, which is related to high plasma levels of lipid-soluble micronutrients such as carotenoids and tocopherols, is linked to lower incidences of various age-related diseases. Differences in lipid-soluble micronutrient blood concentrations seem to be associated with age. Our retrospective analysis included men and women aged 22–37 and 60–85 years from the Berlin Aging Study II. Participants with simultaneously available plasma samples and dietary data were included (n = 1973). Differences between young and old groups were found for plasma lycopene, α-carotene, α-tocopherol, β-cryptoxanthin (only in women), and γ-tocopherol (only in men). β-Carotene, retinol and lutein/zeaxanthin did not differ between young and old participants regardless of the sex. We found significant associations for lycopene, α-carotene (both inverse), α-tocopherol, γ-tocopherol, and β-carotene (all positive) with age. Adjusting for BMI, smoking status, season, cholesterol and dietary intake confirmed these associations, except for β-carotene. These micronutrients are important antioxidants and associated with lower incidence of age-related diseases, therefore it is important to understand the underlying mechanisms in order to implement dietary strategies for the prevention of age-related diseases. To explain the lower lycopene and α-carotene concentration in older subjects, bioavailability studies in older participants are necessary.<br />Graphical abstract Image 1<br />Highlights • Eating fruits and vegetables is linked to lower incidence of age-related diseases. • Different patterns of plasma antioxidant micronutrients in young vs. old subjects. • Lycopene, α-carotene, α-, and γ-tocopherol are associated with age. • Adjusting for BMI, smoking, season, cholesterol and diet confirmed associations. • Underlying mechanism could be altered bioavailability of micronutrients in aging.
- Subjects :
- 0301 basic medicine
Male
Lutein
Aging
Food frequency questionnaire
Clinical Biochemistry
Physiology
Tocopherols
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Plasma
0302 clinical medicine
Age
Medicine
Humans
Micronutrients
Carotenoids
Vitamin A
lcsh:QH301-705.5
Carotenoid
Aged
Retrospective Studies
chemistry.chemical_classification
lcsh:R5-920
Cholesterol
business.industry
Organic Chemistry
Retinol
food and beverages
Micronutrient
Lycopene
Bioavailability
Zeaxanthin
030104 developmental biology
lcsh:Biology (General)
chemistry
Female
lcsh:Medicine (General)
business
030217 neurology & neurosurgery
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....a63375e8c5419e7f5eec774cbc6a3655