Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice

Authors :: Micheal S. Ward
Carmel M. McVicar
M Kolibabka
Andreas Schlotterer
Hans-Peter Hammes
Angelika Bierhaus
Mei Chen
Jasenka Guduric-Fuchs
Liza Colhoun
Thomas Fleming
Alan W. Stitt
Source :: Diabetologia, McVicar, C M, Ward, M, Colhoun, L M, Guduric-Fuchs, J, Bierhaus, A, Fleming, T, Schlotterer, A, Kolibabka, M, Hammes, H-P, Chen, M & Stitt, A W 2015, ' Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice ', Diabetologia, vol. 58, no. 5, pp. 1129-37 . https://doi.org/10.1007/s00125-015-3523-x
Publication Year :: 2015
Publisher :: Springer Berlin Heidelberg, 2015.
Abstract: Aims/hypothesis The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy. Methods Diabetes was induced in wild-type (WT) and Rage−/− mice (also known as Ager−/− mice) using streptozotocin while non-diabetic control mice received saline. For all groups, blood glucose, HbA1c and retinal levels of methylglyoxal (MG) were evaluated up to 24 weeks post diabetes induction. After mice were killed, retinal glia and microglial activation, vasopermeability, leucostasis and degenerative microvasculature changes were determined. Results Retinal expression of RAGE in WT diabetic mice was increased after 12 weeks (p

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