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Osteoarthritis in osteogenesis imperfecta: A nationwide register-based cohort study
- Source :
- Andersen, J D, Folkestad, L, Hald, J D, Harsløf, T, Langdahl, B L & Abrahamsen, B 2022, ' Osteoarthritis in osteogenesis imperfecta : A nationwide register-based cohort study ', Bone, vol. 154, 116222 . https://doi.org/10.1016/j.bone.2021.116222, Andersen, J D, Folkestad, L, Hald, J D, Harsløf, T, Langdahl, B L & Abrahamsen, B 2022, ' Osteoarthritis in osteogenesis imperfecta : A nationwide register-based cohort study ', bone, vol. 154, 116222 . https://doi.org/10.1016/j.bone.2021.116222
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- BACKGROUND: Osteogenesis Imperfecta (OI) is a genetic disease characterized by skeletal fragility. Collagen type 1 is found in many tissues and collagen abnormalities may result in organ specific symptomatology. Musculoskeletal pain is a known issue for patients with OI, osteoarthritis (OA) can be a likely cause. Only few studies have investigated the relationship between OI and OA but demonstrated a greater propensity in OI patients to develop rapidly progressing OA. Therefore, we wanted to investigate if OA is more frequent in patients with OI compared to the general population.OBJECTIVE: To evaluate the risk of osteoarthritis in patients with OI.DESIGN: A Danish nationwide, population-based and register-based longitudinal open cohort study.PARTICIPANTS: From 1977 to 2019, all patients registered with an OI diagnosis and a reference population matched on age and sex 5:1.MEASUREMENTS: Sub-hazard ratios for any, hip, and knee osteoarthritis comparing the OI cohort to the reference population.RESULTS: We identified 907 patients with OI (493 women) and included 4535 patients in the reference population (2465 women). The Sub Hazard Ratio was 2.20 [95% CI 1.73-2.79] for any osteoarthritis with 11.4% of the OI population and 5.4% of the reference population being registered. We found lower incidences of upper extremity joint OA compared to lower joint OA, but upper extremity joint OA was significantly more frequent in the OI population 2.1% vs 0.6%, SHR 3.19 [95% CI 1.78-5.70].CONCLUSION: Patients with OI have a higher risk of OA than the reference population.MINIABSTRACT: Osteogenesis Imperfecta (OI) is a hereditary connective tissue disorder with skeletal fragility and extraskeletal manifestations. Osteoarthritis is a frequent joint disease and the incidence increases with age. In a population-register-based study, the risk of osteoarthritis was higher in patients with OI at an earlier age compared to a reference population.
- Subjects :
- medicine.medical_specialty
Histology
Epidemiology
Physiology
Endocrinology, Diabetes and Metabolism
Population
Osteoarthritis
KNEE OSTEOARTHRITIS
DISEASE
Collagen Type I
Cohort Studies
Internal medicine
medicine
Humans
Longitudinal Studies
education
RISK
education.field_of_study
HIP
business.industry
Incidence (epidemiology)
Hazard ratio
DEATH
Osteoarthritis, Knee
Osteogenesis Imperfecta
medicine.disease
Register based nationwide
Osteogenesis imperfecta
Cohort
Female
Connective tissue disorders
HEALTH
business
Cohort study
Subjects
Details
- ISSN :
- 87563282
- Volume :
- 154
- Database :
- OpenAIRE
- Journal :
- Bone
- Accession number :
- edsair.doi.dedup.....a6280af5451d2babeee44eb608a2727b