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rna interference and micro rna –oriented therapy in cancer: rationales, promises, and challenges
- Source :
- Current Oncology
- Publication Year :
- 2009
- Publisher :
- Multimed Inc., 2009.
-
Abstract
- The discovery that rna interference (rnai) and its functional derivatives, small interfering rnas (sirnas) and micro-rnas (mirnas) could mediate potent and specific gene silencing has raised high hopes for cancer therapeutics. The prevalence of these small (18–25 nucleotide) non-coding rnas in human gene networks, coupled with their unique specificity, has paved the way for the development of new and promising therapeutic strategies in re-directing or inhibiting small rna phenomena. Three strategies are currently being developed: (1) De novo rnai programming using synthetic sirnas to target the expression of genes; (2) Strengthening or recapitulation of the physiologic targeting of messenger rnas by specific mirnas; (3) Sequence-specific inhibition of mirna functions by nucleic acid analogs. Each strategy, currently being developed both in academia and in industry, holds promise in cancer therapeutics.
Details
- Language :
- English
- ISSN :
- 17187729 and 11980052
- Volume :
- 16
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Current Oncology
- Accession number :
- edsair.doi.dedup.....a623871aa0167219807c2e7a49cd24ed