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Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literature

Authors :
Mert Saynak
Sernaz Uzunoglu
Bengu Denizli
Hakan Karagol
Cem Uzal
Rusen Cosar-Alas
Nurettin Aydogdu
Alaattin Özen
Aykan Alas
Zafer Kocak
Source :
Journal of Cancer Research and Therapeutics, Vol 6, Iss 4, Pp 557-559 (2010)
Publication Year :
2010
Publisher :
Wolters Kluwer Medknow Publications, 2010.

Abstract

Spontaneous intracranial hypotension (SICH) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. Postural headache in patients should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal gadolinium enhancement and subdural effusion. It may mimic central nervous system (CNS) metastasis. Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the gadolinium enhancement as CNS metastasis is an important issue. Capecitabine is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. SICH might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic patients suffering from intracranial hypotension. We report a case of spontaneous intracranial hypotension during capecitabine treatment. Patient was completely well following drug discontinuation and supportive treatment.

Details

Language :
English
ISSN :
19984138 and 09731482
Volume :
6
Issue :
4
Database :
OpenAIRE
Journal :
Journal of Cancer Research and Therapeutics
Accession number :
edsair.doi.dedup.....a5ffd624c29890e0d295fabc8bd5fd45