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Nitric oxide donor induces HSP70 accumulation in the heart and in cultured cells
- Source :
- FEBS Letters. 391:21-23
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- As our group has shown, the NO-synthase inhibitor L-NNA decreased 2–3 times heat shock-induced synthesis of the heat shock protein HSP70 (FEBS Lett. 370 (1995) 159–162). It was suggested that NO is involved in such induction. In the present study, it was found that (1) injection of the NO donor dinitrosyl iron complex (DNIC) into rats results in accumulation of HSP70 in the heart; (2) heat shock is accompanied by increased generation of NO (EPR assay) and HSP70 accumulation in cultured cells; (3) DNIC induces HSP70 accumulation in cultured cells not exposed to heat shock.
- Subjects :
- Hepatoblastoma
Male
Hot Temperature
Dinitrosyl iron complex
Iron
Kinetics
Biophysics
Blood Pressure
Biochemistry
Cell Line
No donors
Nitric oxide
chemistry.chemical_compound
Structural Biology
Heat shock protein
Tumor Cells, Cultured
Genetics
medicine
Animals
Humans
HSP70 Heat-Shock Proteins
Rats, Wistar
Molecular Biology
Chemistry
Myocardium
Liver Neoplasms
Electron Spin Resonance Spectroscopy
Heart
Cell Biology
Molecular biology
Rats
Hsp70
Western blot analysis
Cell culture
Shock (circulatory)
Nitrogen Oxides
Electron paramagnetic resonance
medicine.symptom
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 391
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....a5f99fac771309a6ca44ce38f44ee849