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Imaging the extent and location of spatiotemporally distributed epileptiform sources from MEG measurements
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 33, Iss, Pp 102903-(2022)
- Publication Year :
- 2021
- Publisher :
- Cold Spring Harbor Laboratory, 2021.
-
Abstract
- Highlights • Evaluation of epilepsy source extent estimation from MEG measurements. • FAST-IRES gave robust location and extent estimation under different noise levels. • Epileptic sources were estimated from interictal discharges in drug-resistant epilepsy patients. • FAST-IRES outperformed LCMV in both simulation and patient data analysis.<br />Non-invasive MEG/EEG source imaging provides valuable information about the epileptogenic brain areas which can be used to aid presurgical planning in focal epilepsy patients suffering from drug-resistant seizures. However, the source extent estimation for electrophysiological source imaging remains to be a challenge and is usually largely dependent on subjective choice. Our recently developed algorithm, fast spatiotemporal iteratively reweighted edge sparsity minimization (FAST-IRES) strategy, has been shown to objectively estimate extended sources from EEG recording, while it has not been applied to MEG recordings. In this work, through extensive numerical experiments and real data analysis in a group of focal drug-resistant epilepsy patients’ interictal spikes, we demonstrated the ability of FAST-IRES algorithm to image the location and extent of underlying epilepsy sources from MEG measurements. Our results indicate the merits of FAST-IRES in imaging the location and extent of epilepsy sources for pre-surgical evaluation from MEG measurements.
- Subjects :
- Drug Resistant Epilepsy
Source extent imaging
Computer science
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
Electrophysiological source imaging (ESI)
Electroencephalography
Eeg recording
Epilepsy
medicine
Magnetoencephalography (MEG)
Humans
Radiology, Nuclear Medicine and imaging
Ictal
Source imaging
RC346-429
medicine.diagnostic_test
business.industry
fungi
Brain
Magnetoencephalography
Regular Article
Pattern recognition
medicine.disease
Magnetic Resonance Imaging
Neurology
Presurgical planning
Neurology (clinical)
Neurology. Diseases of the nervous system
Epilepsies, Partial
Artificial intelligence
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 33, Iss, Pp 102903-(2022)
- Accession number :
- edsair.doi.dedup.....a5f98dd45e017c994db3ae4b3acaceb5