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Spirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core
- Source :
- Journal of the American Chemical Society. 129(3)
- Publication Year :
- 2007
-
Abstract
- The new macrolide spirastrellolide B (5) has been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Chemical transformations of spirastrellolide B have converted it to a bromine-containing crystalline derivative 8 that has a truncated side chain. Single-crystal X-ray diffraction analysis of the derivative 8 has revealed the absolute configuration of the macrolide core of spirstrellolide B to be 3R,7S,9S,11S,13R,14S,17S,20S,21R, 22S,23S,24S,27R,29S,31R,34S,35R,37S,38S.
- Subjects :
- Chemistry
Stereochemistry
Absolute configuration
Molecular Conformation
General Chemistry
Biochemistry
Catalysis
Molecular conformation
Anti-Bacterial Agents
Crystallography
chemistry.chemical_compound
Colloid and Surface Chemistry
Side chain
Spirastrellolide B
Spiro Compounds
Macrolides
Spirastrella coccinea
Derivative (chemistry)
Subjects
Details
- ISSN :
- 00027863
- Volume :
- 129
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....a5f66b42692dd09fb22dd74315977116