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Therapeutic strategies involving survivin inhibition in cancer
- Source :
- Dipòsit Digital de la UB, Universidad de Barcelona, Repositorio Institucional de la Universidad de Burgos (RIUBU), instname
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Survivin is a small protein that belongs to the inhibitor of apoptosis protein family. It is abundantly expressed in tumors compared with adult differentiated tissues, being associated with poor prognosis in many human neoplasms. This apoptotic inhibitor has a relevant role in both the promotion of cancer cell survival and in the inhibition of cell death. Consequently, aberrant survivin expression stimulates tumor progression and confers resistance to several therapeutic strategies in a variety of tumors. In fact, efficient survivin downregulation or inhibition results in spontaneous apoptosis or sensitization to chemotherapy and radiotherapy. Therefore, all these features make survivin an attractive therapeutic target to treat cancer. Currently, there are several survivin inhibitors under clinical evaluation, although more specific and efficient survivin inhibitors are being developed. Moreover, novel combination regimens targeting survivin together with other therapeutic approaches are currently being designed and assessed. In this review, recent progress in the therapeutic options targeting survivin for cancer treatment is analyzed. Direct survivin inhibitors and their current development status are explored. Besides, the major signaling pathways implicated in survivin regulation are described and different therapeutic approaches involving survivin indirect inhibition are evaluated. Finally, promising novel inhibitors under preclinical or clinical evaluation as well as challenges of developing survivin inhibitors as a new therapy for cancer treatment are discussed.<br />Consejería de Educación, Junta de Castilla y León. Grant Number: BU092U16 Instituto de Salud Carlos III. Grant Number: FIS PI18/00441
- Subjects :
- SMAC mimetics
Cellular signal transduction
Programmed cell death
inhibitor ofapoptosis proteins
Survivin
medicine.medical_treatment
Chemistry, Organic
Antineoplastic Agents
Inhibitor of apoptosis
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Neoplasms
Drug Discovery
medicine
Humans
Molecular Targeted Therapy
anticancer therapy
Patologia molecular
Càncer
neoplasms
Cancer
Inhibition
030304 developmental biology
Molecular pathology
Pharmacology
0303 health sciences
business.industry
apoptosis
chemoresistance
Química orgánica
Transducció de senyal cel·lular
Cell Differentiation
survivin inhibitors
medicine.disease
Radiation therapy
Inhibició
Tumor progression
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Molecular Medicine
business
Signal Transduction
Subjects
Details
- ISSN :
- 10981128 and 01986325
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Medicinal Research Reviews
- Accession number :
- edsair.doi.dedup.....a5ed7db9ffb2fd15982af6265c8418a6