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Ancient retroviral insertions among human populations
- Source :
- Journal of Human Genetics. 51:353-362
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Human endogenous retroviruses (HERVs) represent vestiges of ancient infections that resulted in stable integration of the viral genome. These insertional elements of viral origin are in fact molecular fossils and, as such, a source of evolutionary information. A family of HERV insertions designated HERV-K includes members that are still polymorphic for the original insertional event. The goal of this report is to describe a novel genetic marker system based on polymorphic retroviral insertions (PRVIs) and to assess its potential usefulness in human population genetic analyses. The allelic frequencies of four insertionally polymorphic HERV-K loci were analyzed in nine geographically targeted, worldwide populations. A polymerase chain reaction assay was employed to examine the frequencies of the provirus and/or solo long terminal repeat insertions at these four loci. Several statistical and phylogenetic analyses were performed based on the frequency data. The phylogenetic relationships observed among the nine populations based on the four retroviral HERV-K loci are consistent not only with prior genetic analyses with other traditional marker systems but also with reported historical and biogeographical data. These polymorphic endogenous retroviral sequences display features that make them excellent tools for forensic and population genetic studies.
- Subjects :
- Genetic Markers
Heterozygote
viruses
Population
Biology
Polymerase Chain Reaction
Evolution, Molecular
Gene Frequency
Phylogenetics
Genetic variation
Genetics
Humans
education
Alleles
Phylogeny
Genetics (clinical)
education.field_of_study
Polymorphism, Genetic
Phylogenetic tree
Endogenous Retroviruses
Terminal Repeat Sequences
Genetic Variation
DNA
Nucleic acid amplification technique
Provirus
Long terminal repeat
Mutagenesis, Insertional
Genetics, Population
Genetic marker
Data Interpretation, Statistical
Nucleic Acid Amplification Techniques
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....a5e0d501f7f52ca9cd6125e3049a0918