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C reactive protein as a predictor of neutrophil recovery in autoimmune neutropenia
- Source :
- International Immunopharmacology. 11:774-777
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Primary autoimmune neutropenia (AIN) is more common in newborns, and usually benign or self-limiting, so most cases require no specific therapy. In adults, however, for little tendency toward spontaneous remission, they require certain treatments and careful managements. Here we report a successful management of primary AIN patient by estimating the granulopoiesis according to CRP levels without administration of G-CSF or increase of prednisolone when peripheral neutrophil counts dropped down. Transient elevation of CRP associated with severe drop down in neutrophil count, and subsequent dramatic neutrophil increase was occasionally observed during the follow up with minimal dose of prednisolone. Coexistence of decreased neutrophil counts and elevated CRP levels was accompanied by increase of serum levels of IL-6 and IL-8. Although this is the report of only one patient, these elevated CRP levels combined with severe drop down and subsequently spontaneous rapid recovery in neutrophil count, were repetitively observed, suggesting the preceding CRP elevation before neutrophil recovery. We propose the important part of CRP as a predictor of granulopoiesis in patients with neutropenia.
- Subjects :
- Neutropenia
Neutrophils
Immunology
Cell Count
Spontaneous remission
Granulocyte
Granulopoiesis
Autoimmune Diseases
medicine
Humans
Immunology and Allergy
Pharmacology
Leukopenia
Interleukin-6
business.industry
Interleukin-8
Middle Aged
Prognosis
medicine.disease
C-Reactive Protein
medicine.anatomical_structure
Autoimmune neutropenia
Prednisolone
Absolute neutrophil count
Female
medicine.symptom
business
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 15675769
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- International Immunopharmacology
- Accession number :
- edsair.doi.dedup.....a5de472a224a974cd7c0772ae2da7643