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The role of age in neuroblastoma risk stratification: the German, Italian, and children's oncology group perspectives
- Source :
- Cancer Letters. 228:257-266
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cut-off currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand, Switzerland, Netherlands). In general, the results are in agreement regarding the prognostic contribution of age. There is strong evidence to support an increase in the age cut-off to a value in the range of 15-18 months based on the results from the German analysis and two COG analyses. However, Italian results in INSS stage 4 patients show that outcome in patients 12-17 months is not better than that of older patients. Further analyses are warrented.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
MEDLINE
Medical Oncology
German
Neuroblastoma
Cog
Risk groups
Older patients
Risk Factors
Germany
Internal medicine
medicine
Humans
In patient
Stage (cooking)
Child
business.industry
Age Factors
language.human_language
Italy
Risk stratification
language
business
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 228
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....a5d568c117416b6b7c781a94b2701479