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Elevated neuropeptide Y gene expression and release during hypoglycemic stress
- Source :
- Peptides. 18(9)
- Publication Year :
- 1997
-
Abstract
- Han, S. P., X. Chen, Y. M. Wu, L. Naes and T. C. Westfall. Elevated neuropeptide Y gene expression and release during hypoglycemic stress. Peptides 18(9) 1335–1340, 1997.—Our previous studies show that neuropeptide Y (NPY) is involved in mediating sympathetic nerve stimulation-induced vasoconstriction. Insulin hypoglycemia is known to produce increased sympathetic output and elevated arterial pressure. The present study examined the role of NPY in the hypertensive response to insulin by examining the effects of insulin on NPY gene expression, tissue content and release. Subcutaneous injection of insulin produced an immediate increase in plasma NPY immunoreactivity (NPYir) and delayed increases in adrenal and neuronal NPY mRNA and adrenal NPYir in rats. These results suggest that NPY may play a role in insulin-induced hypertension.
- Subjects :
- Male
medicine.medical_specialty
Nicotine
Physiology
Npy mrna
medicine.medical_treatment
Neuropeptide Y Gene
Superior Cervical Ganglion
Biochemistry
Rats, Sprague-Dawley
Cellular and Molecular Neuroscience
Subcutaneous injection
Endocrinology
Stress, Physiological
Internal medicine
mental disorders
Gene expression
Medicine
Animals
Hypoglycemic Agents
Insulin
Neuropeptide Y
Nicotinic Agonists
business.industry
Neuropeptide Y receptor
Denervation
humanities
Hypoglycemia
Rats
Blood pressure
Gene Expression Regulation
Adrenal Medulla
Hypertension
medicine.symptom
business
Vasoconstriction
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 18
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....a5cd3f0024e0f7e06b15f7e9d86953e6