Back to Search
Start Over
Multi-component quantitation of loratadine, pseudoephedrine and paracetamol in plasma and pharmaceutical formulations with liquid chromatography-tandem mass spectrometry utilizing a monolithic column
- Source :
- Química Nova, Volume: 35, Issue: 10, Pages: 1950-1954, Published: 2012, Química Nova v.35 n.10 2012, Química Nova, Sociedade Brasileira de Química (SBQ), instacron:SBQ, Química Nova, Vol 35, Iss 10, Pp 1950-1954 (2012)
- Publication Year :
- 2012
- Publisher :
- Sociedade Brasileira de Química, 2012.
-
Abstract
- The purpose of this study was to develop a rapid, simple and sensitive quantitation method for pseudoephedrine (PSE), paracetamol (PAR) and loratadine (LOR) in plasma and pharmaceuticals using liquid chromatography-tandem mass spectrometry with a monolithic column. Separation was achieved using a gradient composition of methanol-0.1% formic acid at a flow rate of 1.0 mL min-1. Mass spectral transitions were recorded in SRM mode. System validation was evaluated for precision, specificity and linearity. Limit of detection for pseudoephedrine, paracetamol, and loratadine were determined to be 3.14, 1.86 and 1.44 ng mL-1, respectively, allowing easy determination in plasma with % recovery of 93.12 to 101.56%.
- Subjects :
- Detection limit
antihistamines
Monolithic HPLC column
Chromatography
Chemistry
Formic acid
liquid chromatography-tandem MS
Analytical chemistry
General Chemistry
Plasma
Loratadine
Pseudoephedrine
Mass spectrometry
lcsh:Chemistry
chemistry.chemical_compound
lcsh:QD1-999
decongestants
Liquid chromatography–mass spectrometry
medicine
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Química Nova, Volume: 35, Issue: 10, Pages: 1950-1954, Published: 2012, Química Nova v.35 n.10 2012, Química Nova, Sociedade Brasileira de Química (SBQ), instacron:SBQ, Química Nova, Vol 35, Iss 10, Pp 1950-1954 (2012)
- Accession number :
- edsair.doi.dedup.....a5cc9e1899b775f0128af2bf0313ad03