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Immunomodulation against leukemias and lymphomas: A realistic future treatment?
- Source :
- Critical Reviews in Oncology/Hematology. 65:101-108
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Immunotherapy offers the potential for cure of malignancy without the side effects too commonly seen with conventional chemotherapy. The efficacy of allogenic transplantation and monoclonal antibodies in hematological malignancies illustrate this principle and are now part of routine care. Newer cell based and molecular approaches aimed at stimulating cytotoxic activity against host derived tumor associated antigens are able to ‘boost’ anti-tumor immunity as judged by immunological assays in vitro . Although clinically meaningful responses were originally less evident, more promising results are now being reported. Our growing understanding of tumor immunology provide rationales for further improvements in the field.
- Subjects :
- Clinical Trials as Topic
Leukemia
Lymphoma
business.industry
medicine.drug_class
medicine.medical_treatment
Cancer
Hematology
Immunotherapy
medicine.disease
Monoclonal antibody
Malignancy
Cancer Vaccines
Killer Cells, Natural
Oncology
Immunity
Immunology
Humans
Medicine
Cytotoxic T cell
business
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 10408428
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Oncology/Hematology
- Accession number :
- edsair.doi.dedup.....a5c2c596c859e3d8407f4a778cd4fa6d