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Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety
- Source :
- Journal of Medicinal Chemistry. 39:661-664
- Publication Year :
- 1996
- Publisher :
- American Chemical Society (ACS), 1996.
- Subjects :
- chemistry.chemical_classification
Farnesyl-diphosphate farnesyltransferase
biology
Stereochemistry
Guinea Pigs
Administration, Oral
Ether
Prodrug
Chemical synthesis
Rats
chemistry.chemical_compound
Squalene
Farnesyl-Diphosphate Farnesyltransferase
chemistry
Enzyme inhibitor
Drug Discovery
biology.protein
Animals
Molecular Medicine
Moiety
Prodrugs
Enzyme Inhibitors
Sulfonic Acids
Alkyl
Hypolipidemic Agents
Subjects
Details
- ISSN :
- 15204804 and 00222623
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....a5b70c081e9fadb62956e1df3d4864d8
- Full Text :
- https://doi.org/10.1021/jm950735s