Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells

Authors :: X. T. Zou
Jianping Wang
Yan Ma
Yizhen Shi
Q. J. Wu
Source :: Poultry Science, Poultry Science, Vol 99, Iss 11, Pp 5802-5813 (2020)
Publication Year :: 2020
Publisher :: Elsevier BV, 2020.
Abstract: Mercuric chloride (HgCl2) is a serious environmental toxicant. So far, the toxicity mechanism of HgCl2 in chicken embryonic kidney (CEK) cells is not still fully understood. In this study, the possible molecular mechanisms of HgCl2 on apoptosis of CEK cells were investigated. Results showed that the cell morphology changed, and cell viability was significantly decreased (P

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