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Patterns of plasma glucagon dynamics do not match metabolic phenotypes in young women
- Source :
- J. Clin. Endocrinol. Metab. 103, 972-982 (2017)
- Publication Year :
- 2017
- Publisher :
- Oxford Univ Press Inc, 2017.
-
Abstract
- Context: The role of hyperglucagonemia in type 2 diabetes is still debated. Objective: We analyzed glucagon dynamics during oral glucose tolerance tests (oGTTs) in young women with one out of three metabolic phenotypes: healthy control (normoglycemic after a normoglycemic pregnancy), normoglycemic high-risk (normoglycemic after a pregnancy complicated by gestational diabetes), and prediabetes/screening-diagnosed type 2 diabetes. We asked if glucagon patterns were homogeneous within the metabolic phenotypes. Design and Setting: Five-point oGTT, sandwich enzyme-linked immunosorbent assay for glucagon, and functional data analysis with unsupervised clustering. Participants: Cross-sectional analysis of 285 women from the monocenter observational study Prediction, Prevention, and Subclassification of gestational and type 2 Diabetes, recruited between November 2011 and May 2016. Results: We found four patterns of glucagon dynamics that did not match the metabolic phenotypes. Elevated fasting glucagon and delayed glucagon suppression was overrepresented with prediabetes/diabetes, but this was only detected in 21% of this group. It also occurred in 8% of the control group. Conclusions: We conclude that hyperglucagonemia may contribute to type 2 diabetes in a subgroup of affected individuals but that it is not a sine qua non for the disease. This should be considered in future pathophysiological studies and when testing pharmacotherapies addressing glucagon signaling.
- Subjects :
- 0301 basic medicine
Adult
Blood Glucose
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
030209 endocrinology & metabolism
Context (language use)
Type 2 diabetes
Biochemistry
Glucagon
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pregnancy
Internal medicine
Diabetes mellitus
medicine
Humans
Prediabetes
business.industry
Biochemistry (medical)
Glucose Tolerance Test
medicine.disease
Gestational diabetes
Diabetes, Gestational
030104 developmental biology
Cross-Sectional Studies
Phenotype
Diabetes Mellitus, Type 2
Case-Control Studies
Female
business
hormones, hormone substitutes, and hormone antagonists
Hyperglucagonemia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J. Clin. Endocrinol. Metab. 103, 972-982 (2017)
- Accession number :
- edsair.doi.dedup.....a5b0e9e09f89d0ba1dfc8fc1a58e96fe