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Pediatric Asthma and Viral Infection
- Source :
- Archivos De Bronconeumologia
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are the most importance risk factors for the onset of wheezing in infants and small children. Bronchiolitis is the most common acute respiratory infection in children under 1 year of age, and the most common cause of hospitalization in this age group. RSV accounts for approximately 70% of all these cases, followed by rhinovirus, adenovirus, metapneumovirus and bocavirus. The association between bronchiolitis caused by RSV and the development of recurrent wheezing and/or asthma was first described more than 40 years ago, but it is still unclear whether bronchiolitis causes chronic respiratory symptoms, or if it is a marker for children with a genetic predisposition for developing asthma in the medium or long term. In any case, sufficient evidence is available to corroborate the existence of this association, which is particularly strong when the causative agent of bronchiolitis is rhinovirus. The pathogenic role of respiratory viruses as triggers for exacerbations in asthmatic patients has not been fully characterized. However, it is clear that respiratory viruses, and in particular rhinovirus, are the most common causes of exacerbation in children, and some type of respiratory virus has been identified in over 90% of children hospitalized for an episode of wheezing. Changes in the immune response to viral infections in genetically predisposed individuals are very likely to be the main factors involved in the association between viral infection and asthma.
- Subjects :
- Hypersensitivity, Immediate
Male
Virus respiratorios
Rhinovirus
viruses
Metapneumovirus humano
Comorbidity
Respiratory syncytial virus
medicine.disease_cause
0302 clinical medicine
Recurrence
Human bocavirus
Prevalence
030212 general & internal medicine
Age of Onset
Child
Respiratory Tract Infections
biology
Respiratory tract infections
Respiratory infection
General Medicine
Bronquiolitis
Causality
Virus Diseases
Child, Preschool
Disease Progression
Bronchiolitis
Respiratory virus
Female
Virus respiratorio sincitial
Adult
Adolescent
Bocavirus humano
Models, Biological
Article
Young Adult
03 medical and health sciences
Human metapneumovirus
medicine
Humans
Asma
Respiratory Sounds
Asthma
Respiratory viruses
business.industry
biology.organism_classification
medicine.disease
respiratory tract diseases
030228 respiratory system
Immunology
business
Rinovirus
Subjects
Details
- ISSN :
- 15792129
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Archivos de Bronconeumología (English Edition)
- Accession number :
- edsair.doi.dedup.....a59bb65a992c4783f03ac3ee6e5215f5