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Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
- Source :
- Molecules, Volume 15, Issue 7, Pages 4924-4933, Molecules (Basel, Online) 15 (2010): 4924–4933., info:cnr-pdr/source/autori:de Vega, MJP ; Garcia-Lopez, MT ; Zaccaro, L ; Royo, M ; Albericio, F ; Fernandez-Carvajal, A ; Ferrer-Montiel, A ; Gonzalez-Muniz, R/titolo:Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers/doi:/rivista:Molecules (Basel, Online)/anno:2010/pagina_da:4924/pagina_a:4933/intervallo_pagine:4924–4933/volume:15, Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, Molecules, Vol 15, Iss 7, Pp 4924-4933 (2010)
- Publication Year :
- 2010
- Publisher :
- Molecular Diversity Preservation International, 2010.
-
Abstract
- Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
- Subjects :
- Drug targeting
Lysine
Pharmaceutical Science
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
Solid-phase synthesis
Drug Discovery
Guanidine
TRPV1 channel blockers
Ciències de la salut
chemistry.chemical_classification
Analgesics
Tryptophan
Dipeptides
Síntesi en fase sólida
Dianes farmacològiques
Chemistry (miscellaneous)
Ion channels
Molecular Medicine
lipids (amino acids, peptides, and proteins)
psychological phenomena and processes
Bioquímica
Trp(Nps) dipeptides
Stereochemistry
TRPV Cation Channels
Medical sciences
Article
lcsh:QD241-441
Structure-Activity Relationship
Analgèsics
lcsh:Organic chemistry
Alkanes
mental disorders
Structure–activity relationship
Channel blocker
Physical and Theoretical Chemistry
Alkyl
Canals iònics
Dipeptide
Organic Chemistry
Proteins
solid-phase
Combinatorial chemistry
solid phase synthesis
chemistry
Proteïnes
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....a599cd317cf42c6437eb2323469ed82b
- Full Text :
- https://doi.org/10.3390/molecules15074924