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Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials
- Source :
- Diabetes, Diabetes 64, 4312-4321 (2015)
- Publication Year :
- 2015
- Publisher :
- American Diabetes Association, 2015.
-
Abstract
- Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of type 2 diabetes (Diabetes Prevention Program [DPP]; N = 917/907 intervention/comparison) or with type 2 diabetes (Look AHEAD [Action for Health in Diabetes]; N = 2,014/1,892 intervention/comparison) were from two parallel arm (lifestyle vs. comparison) randomized controlled trials. The associations of 91 established obesity-predisposing loci with weight loss across 4 years and with weight regain across years 2–4 after a minimum of 3% weight loss were tested. Each copy of the minor G allele of MTIF3 rs1885988 was consistently associated with greater weight loss following lifestyle intervention over 4 years across the DPP and Look AHEAD. No such effect was observed across comparison arms, leading to a nominally significant single nucleotide polymorphism×treatment interaction (P = 4.3 × 10−3). However, this effect was not significant at a study-wise significance level (Bonferroni threshold P < 5.8 × 10−4). Most obesity-predisposing gene variants were not associated with weight loss or regain within the DPP and Look AHEAD trials, directly or via interactions with lifestyle.
- Subjects :
- Male
Risk
medicine.medical_specialty
Diet, Reducing
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
Motor Activity
Overweight
Weight Gain
Polymorphism, Single Nucleotide
Body Mass Index
law.invention
Mitochondrial Proteins
Prediabetic State
Randomized controlled trial
Recurrence
Weight loss
law
Internal medicine
Diabetes mellitus
Weight Loss
Internal Medicine
Humans
Medicine
Genetic Predisposition to Disease
Longitudinal Studies
Obesity
Eukaryotic Initiation Factors
Life Style
Genetic Association Studies
business.industry
Genetics/Genomes/Proteomics/Metabolomics
Middle Aged
medicine.disease
Combined Modality Therapy
3. Good health
Endocrinology
Diabetes Mellitus, Type 2
Female
medicine.symptom
business
Weight gain
Body mass index
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....a5920efe6eb4a894498ef73a9f156726