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Rare subtypes of BK virus are viable and frequently detected in renal transplant recipients with BK virus-associated nephropathy
- Source :
- Virology. 404(2):312-318
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- BK virus-associated nephropathy (BKVN) occurs in up to 5% of kidney transplants and is a significant cause of graft loss. Four major subtypes of BKV have been described, with the vast majority of individuals persistently infected with BKV Type I (>80% of the population). Sequencing of BKV isolates subcloned from BKVN patients revealed a high percentage of variants in the urine (40%) in the VP1 subtyping region. In vitro analysis of several viral variants revealed that all variants recovered from the urine of BKVN patients produced infectious viral particles and were replication competent in cell culture while some of the variants induced cytopathic changes in infected cells when compared to the major BKV subtype, VP1 Type I. These results suggest that rare BKV VP1 variants are more frequently associated with disease and that some variants could be more cytopathic than others in renal transplant recipients.
- Subjects :
- viruses
Population
Urine
Biology
medicine.disease_cause
Cell Line
Nephropathy
Viral Proteins
BK virus
Virology
Chlorocebus aethiops
medicine
Animals
Humans
Polyomavirus-associated nephropathy
Cloning, Molecular
education
Kidney transplant
Vero Cells
Kidney transplantation
BKV
Polyomavirus Infections
Kidney
education.field_of_study
virus diseases
medicine.disease
Kidney Transplantation
Subtyping
Tumor Virus Infections
medicine.anatomical_structure
Amino Acid Substitution
Viral replication
COS Cells
Immunology
Vero cell
Kidney Diseases
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 404
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....a5920b0140c55d278e77f6ff4e5eacc8
- Full Text :
- https://doi.org/10.1016/j.virol.2010.05.012