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NeuroHeal Improves Muscle Regeneration after Injury
- Source :
- Cells, Cells, Vol 10, Iss 22, p 22 (2021), Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Volume 10, Issue 1
- Publication Year :
- 2020
-
Abstract
- Musculoskeletal injuries represent a challenging medical problem. Although the skeletal muscle is able to regenerate and recover after injury, the process engaged with conservative therapy can be inefficient, leading to a high re-injury rate. In addition, the formation of scar tissue implies an alteration of mechanical properties in muscle. There is still a need for new treatments of the injured muscle. NeuroHeal may be one option. Published studies demonstrated that it reduces muscle atrophy due to denervation and disuse. The main objective of the present work was to assess the potential of NeuroHeal to improve muscle regeneration after traumatic injury. Secondary objectives included characterizing the effect of NeuroHeal treatment on satellite cell biology. We used a rat model of sport-induced injury in the gastrocnemius and analyzed the effects of NeuroHeal on functional recovery by means of electrophysiology and tetanic force analysis. These studies were accompanied by immunohistochemistry of the injured muscle to analyze fibrosis, satellite cell state, and fiber type. In addition, we used an in vitro model to determine the effect of NeuroHeal on myoblast biology and partially decipher its mechanism of action. The results showed that NeuroHeal treatment advanced muscle fiber recovery after injury in a preclinical model of muscle injury, and significantly reduced the formation of scar tissue. In vitro, we observed that NeuroHeal accelerated the formation of myotubes. The results pave the way for novel therapeutic avenues for muscle/tendinous disorders.
- Subjects :
- Male
Acamprosate
Muscle Fibers, Skeletal
Sport injury
Bioinformatics
Article
Cell Line
Myoblasts
sport injury
Mice
Sirtuin 1
Fibrosis
Muscle regeneration
Satellite cells
Ribavirin
Medicine
Myocyte
Animals
Regeneration
Rats, Wistar
Muscle, Skeletal
lcsh:QH301-705.5
Denervation
satellite cells
muscle regeneration
business.industry
Myogenesis
Skeletal muscle
General Medicine
Recovery of Function
medicine.disease
Muscle atrophy
Rats
Electrophysiology
Drug Combinations
medicine.anatomical_structure
Traumatic injury
Neuroprotective Agents
lcsh:Biology (General)
Athletic Injuries
NeuroHeal
medicine.symptom
business
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....a5900690b96e370153858fbf94fc22c7