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Comparative genomics of the human and Fugu voltage-gated calcium channel α1-subunit gene family reveals greater diversity in Fugu
- Source :
- Gene. 366:117-127
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Extensive search for the orthologs of 10 human voltage-gated calcium channel (VGCC) alpha(1)-subunit genes in the Fugu genome sequence revealed 21 alpha(1)-subunit genes in the compact genome of Fugu. Subtype classification of the identified Fugu alpha(1) orthologs based on phylogenetic analysis, genomic organization and sequence comparison of the most divergent II/III loop and the C-terminal regions of the alpha(1)-subunits indicated extra copies of alpha(1S)-, alpha(1D)-, alpha(1F)-, alpha(1A)-, alpha(1E)-, alpha(1H)- and alpha(1G)-subunit genes. Phylogenetic analysis reveals that this is likely due to fish lineage specific alpha(1)-subunit subtype duplication. Sequence comparison shows that many of the structural features characteristic of VGCC and specific channel subtypes are also present in the Fugu alpha(1)-subunits. All the Fugu alpha(1)-subunits showed similar expression profile to that of the mammalian alpha(1)-subunits except for Fugu alpha(1S), alpha(1A), alpha(1B) and alpha(1H) which have a more widespread tissue distribution. These results indicate that Fugu, a lower vertebrate, has more extensive channel heterogeneity compared to human.
- Subjects :
- Genetics
Comparative genomics
Whole genome sequencing
Sequence Homology, Amino Acid
Phylogenetic tree
Genome, Human
Fugu
fungi
General Medicine
Biology
Genome
Protein Structure, Tertiary
Takifugu
Sequence Analysis, Protein
Animals
Humans
Gene family
Calcium Channels
Gene
Phylogeny
Genomic organization
Subjects
Details
- ISSN :
- 03781119
- Volume :
- 366
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....a58a9e7a2ccc23f480158eb6eedcdac0