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An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress
- Source :
- Molecular and Cellular Neuroscience. 55:13-16
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress is traditionally thought to play an important role, such as familial and sporadic forms of Alzheimer's disease and other age-related neurodegenerative diseases. This minireview is focused on substantial data that were accumulated over the last 2 decades to support the concept that KGDHC can be a primary mitochondrial target of oxidative stress and at the same time a key contributor to it by producing reactive oxygen species. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.
- Subjects :
- chemistry.chemical_classification
Reactive oxygen species
Reactive oxygen species metabolism
Neurodegeneration
Ketoglutarate dehydrogenase
Cell Biology
Disease
Mitochondrion
Biology
medicine.disease
medicine.disease_cause
Article
Mitochondria
Oxidative Stress
Cellular and Molecular Neuroscience
chemistry
Biochemistry
medicine
Animals
Humans
Ketoglutarate Dehydrogenase Complex
Dehydrogenase complex
Reactive Oxygen Species
Molecular Biology
Oxidative stress
Subjects
Details
- ISSN :
- 10447431
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Neuroscience
- Accession number :
- edsair.doi.dedup.....a57a2e5519fc82c081d655566ef77086