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No evidence for a susceptibility locus predisposing to manic depression in the region of the dopamine (D2) receptor gene
- Source :
- Scopus-Elsevier
-
Abstract
- Recent reports of cytogenetic abnormalities linked to psychiatric illness and the localisations of the genes for the dopamine (D2) receptor and tyrosinase on the long arm of chromosome 11 have suggested that susceptibility loci for schizophrenia and manic depression might be situated in this region. We could find no evidence for linkage in five Icelandic pedigrees between manic depression and markers in this region, and we have excluded candidate genes coding for the D2 receptor and tyrosinase. We conclude that mutations at loci in this region are not a common cause of manic depression in the population studied.
- Subjects :
- Adult
Genetic Markers
Male
Psychosis
medicine.medical_specialty
Candidate gene
Bipolar Disorder
Genetic Linkage
Population
Chromosome Disorders
Locus (genetics)
Biology
behavioral disciplines and activities
Receptors, Dopamine
03 medical and health sciences
0302 clinical medicine
Risk Factors
Dopamine receptor D2
mental disorders
medicine
Humans
030212 general & internal medicine
Psychiatry
education
Gene
Genes, Dominant
Chromosome Aberrations
Genetics
education.field_of_study
Models, Genetic
Receptors, Dopamine D2
Chromosomes, Human, Pair 11
Genetic Carrier Screening
Chromosome Mapping
medicine.disease
Pedigree
030227 psychiatry
Psychiatry and Mental health
Genetic marker
Female
medicine.symptom
DNA Probes
Mania
Polymorphism, Restriction Fragment Length
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....a57076655c35200db906306e3964005f