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Positive Effects of Hydrogen Water on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in NC/Nga Mice
- Source :
- Biological and Pharmaceutical Bulletin. 37:1480-1485
- Publication Year :
- 2014
- Publisher :
- Pharmaceutical Society of Japan, 2014.
-
Abstract
- Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical symptoms. In line with this, the level of reactive oxygen species in the HW group was significantly inhibited compared with that in the purified water (PW) group. In parallel, HW enhanced glutathione peroxidase activity in DNCB-induced AD as compared with the PW group. Accordingly, the levels of thymus and activation-regulated chemokine and cytokines were significantly decreased in the HW group compared with the PW group. Notably, the levels of Th2 cytokine, interleukin-5 (IL-5), and proinflammatory cytokines such as tumor necrosis factor-α and IL-6 in HW-fed mice were significantly lower than in control and PW-fed mice. The total serum immunoglobulin E level was also markedly reduced in the HW group. The collective results indicate that HW suppresses DNCB-induced AD in NC/Nga mice via redox balance and immune modulation and could be a safe clinical fluid treatment for AD.
- Subjects :
- Male
medicine.medical_specialty
Chemokine
Pharmaceutical Science
medicine.disease_cause
Dermatitis, Atopic
2,4-Dinitrochlorobenzene
Allergic inflammation
Proinflammatory cytokine
Leukocyte Count
Mice
chemistry.chemical_compound
Malondialdehyde
Internal medicine
Dinitrochlorobenzene
medicine
Animals
Pharmacology
chemistry.chemical_classification
Glutathione Peroxidase
Reactive oxygen species
biology
Chemistry
Water
General Medicine
Atopic dermatitis
Immunoglobulin E
medicine.disease
Endocrinology
biology.protein
Cytokines
Tumor necrosis factor alpha
Reactive Oxygen Species
Oxidative stress
Hydrogen
Subjects
Details
- ISSN :
- 13475215 and 09186158
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Biological and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....a55318789572ca53d0740ca6d0e44fa7