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Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study
- Source :
- BMC Medicine, BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim of this study was to investigate the associations of six adiposity markers with incidence and mortality from 24 cancers by accounting for potential non-linear associations. Methods A total of 437,393 participants (53.8% women; mean age 56.3 years) from the UK Biobank prospective cohort study were included in this study. The median follow-up was 8.8 years (interquartile range 7.9 to 9.6) for mortality and 9.3 years (IQR 8.6 to 9.9) for cancer incidence. Adiposity-related exposures were BMI, body fat percentage, waist-hip ratio, waist-height ratio, and waist and hip circumference. Incidence and mortality of 24 cancers sites were the outcomes. Cox proportional hazard models were used with each of the exposure variables fitted separately on penalised cubic splines. Results During follow-up, 47,882 individuals developed cancer and 11,265 died due to cancer during the follow-up period. All adiposity markers had similar associations with overall cancer incidence. BMI was associated with a higher incidence of 10 cancers (stomach cardia (hazard ratio per 1 SD increment 1.35, (95% CI 1.23; 1.47)), gallbladder (1.33 (1.12; 1.58)), liver (1.27 (1.19; 1.36)), kidney (1.26 (1.20; 1.33)), pancreas (1.12 (1.06; 1.19)), bladder (1.09 (1.04; 1.14)), colorectal (1.10 (1.06; 1.13)), endometrial (1.73 (1.65; 1.82)), uterine (1.68 (1.60; 1.75)), and breast cancer (1.08 (1.05; 1.11))) and overall cancer (1.03 (1.02; 1.04)). All these associations were linear except for breast cancer in postmenopausal women. Similar results were observed when other markers of central and overall adiposity were used. For mortality, nine cancer sites were linearly associated with BMI and eight with waist circumference and body fat percentage. Conclusion Adiposity, regardless of the marker used, was associated with an increased risk in 10 cancer sites.
- Subjects :
- Adult
Male
medicine.medical_specialty
UK Biobank
Waist
lcsh:Medicine
Body Mass Index
RC0254
RC1200
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Breast cancer
Risk Factors
Internal medicine
Neoplasms
medicine
Biomarkers, Tumor
Humans
030212 general & internal medicine
Obesity
Prospective Studies
Risk factor
Prospective cohort study
Cancer
Adiposity
Aged
Proportional Hazards Models
business.industry
Waist-Hip Ratio
Incidence (epidemiology)
Incidence
lcsh:R
Hazard ratio
General Medicine
Middle Aged
medicine.disease
United Kingdom
Body fat
030220 oncology & carcinogenesis
Waist circumference
Female
business
Body mass index
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17417015
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Medicine
- Accession number :
- edsair.doi.dedup.....a54a97ffc30786fcfcde706d8776909e