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Cell Distribution Differences Of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Patients With Kawasaki Disease
Cell Distribution Differences Of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Patients With Kawasaki Disease
- Source :
- Pediatric Infectious Disease Journal. 31:973-974
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- The interaction of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase-1 has been implicated in the formation of coronary aneurysms in Kawasaki disease. MMP-9 and tissue inhibitor of matrix metalloproteinase-1 were distributed predominantly in the granulocytes and platelets, respectively, in patients with Kawasaki disease. The plasma values of MMP-9 correlated positively with the circulating neutrophil count. Inhibiting the activity of granulocytes and maintaining the platelet activity might prevent coronary aneurysms.
- Subjects :
- Blood Platelets
Male
Microbiology (medical)
Pathology
medicine.medical_specialty
Cell
Mucocutaneous Lymph Node Syndrome
Matrix metalloproteinase
Matrix (biology)
Leukocyte Count
Leukocytes
Humans
Medicine
Distribution (pharmacology)
Platelet
cardiovascular diseases
Platelet activation
Tissue Inhibitor of Metalloproteinase-1
business.industry
Coronary Aneurysm
Immunoglobulins, Intravenous
Infant
Blood Proteins
medicine.disease
Infectious Diseases
medicine.anatomical_structure
Matrix Metalloproteinase 9
Case-Control Studies
Child, Preschool
Pediatrics, Perinatology and Child Health
Absolute neutrophil count
Female
Kawasaki disease
business
Subjects
Details
- ISSN :
- 08913668
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Pediatric Infectious Disease Journal
- Accession number :
- edsair.doi.dedup.....a5473a47cae1874b1ecfd9d8b50f4e68
- Full Text :
- https://doi.org/10.1097/inf.0b013e31825ba6b3