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Cell Distribution Differences Of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Patients With Kawasaki Disease

Cell Distribution Differences Of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Patients With Kawasaki Disease

Authors :
Tatsuro Izumi
Seigo Korematsu
Chika Goto
Hiroaki Miyahara
Masahiro Takeguchi
Yoko Ohta
Tatsuya Kawano
Naotaka Tamai
Source :
Pediatric Infectious Disease Journal. 31:973-974
Publication Year :
2012
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2012.

Abstract

The interaction of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase-1 has been implicated in the formation of coronary aneurysms in Kawasaki disease. MMP-9 and tissue inhibitor of matrix metalloproteinase-1 were distributed predominantly in the granulocytes and platelets, respectively, in patients with Kawasaki disease. The plasma values of MMP-9 correlated positively with the circulating neutrophil count. Inhibiting the activity of granulocytes and maintaining the platelet activity might prevent coronary aneurysms.

Details

ISSN :
08913668
Volume :
31
Database :
OpenAIRE
Journal :
Pediatric Infectious Disease Journal
Accession number :
edsair.doi.dedup.....a5473a47cae1874b1ecfd9d8b50f4e68
Full Text :
https://doi.org/10.1097/inf.0b013e31825ba6b3