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Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 7228, p 7228 (2020), International Journal of Molecular Sciences, Volume 21, Issue 19
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Psoriasis is a common chronic inflammatory skin condition manifested by T cell responses and characterized by preferential recurrence at previously inflamed sites upon withdrawal of treatment. The site-specific disease memory in psoriasis has been linked to CD8+CD103+ tissue-resident memory T cells (Trm) in the epidermis which were previously thought to only provide &ldquo<br />frontline&rdquo<br />protection against pathogens and immunosurveillance during cancer development. In this study, we correlated the presence of a subset of the Trm cells which are also CD49a+ with disease severity in human psoriatic lesions with acute and chronic disease. Using an imiquimod (IMQ)-induced murine model of psoriasiform dermatitis, we also investigated the level of CD49a+ Trm cells in acute, chronic and resolved psoriatic lesions. Investigation of clinical human samples showed that patient disease severity highly correlated with the numbers of epidermal CD49a+ Trm cells. Additionally, this subset of Trm cells was shown to persist in resolved lesions of murine psoriasiform dermatitis once clinical disease features had subsided. Importantly, these CD49a+ Trm cells showed significantly higher levels of granzyme B (GzmB) production compared to acute disease, suggesting a potential role of CD49a+ Trm cells for psoriatic re-occurrence in resolved patients. Better understanding of epidermal CD49a+ Trm cell activity is necessary for development of advanced treatment strategies for psoriasis to permit long-term, continuous disease control.
- Subjects :
- tissue-resident memory T cells
T-Lymphocytes
T cell
Integrin alpha1
Imiquimod
Granzymes
Article
Catalysis
GZMB
Inorganic Chemistry
lcsh:Chemistry
Mice
Psoriasis
Animals
Humans
Medicine
Cell Lineage
Physical and Theoretical Chemistry
Molecular Biology
Psoriasiform Dermatitis
lcsh:QH301-705.5
Spectroscopy
resolved lesions
business.industry
Organic Chemistry
General Medicine
psoriasis
medicine.disease
Computer Science Applications
Granzyme B
Immunosurveillance
Disease Models, Animal
medicine.anatomical_structure
Gene Expression Regulation
lcsh:Biology (General)
lcsh:QD1-999
Immunology
Epidermis
business
Immunologic Memory
CD8
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 7228
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....a541b7bb8db64618be00fa62c44a4fc2