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Clinical and prognostic role of matrix metalloproteinase-2, -9 and their inhibitors in breast cancer and liver diseases: A review
- Source :
- The International Journal of Biochemistry & Cell Biology. 77:91-101
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Matrix metalloproteinases are a family of zinc endopeptidases with proteolytic activity against the extracellular matrix components. In particular, two members of this family named Gelatinase A and B, as amply documented in the literature, play a key role in the process of tumor growth/metastasis in breast and hepatocellular carcinoma. Their activity is regulated by Tissue Inhibitor of metalloproteinases-1 and -2, which are the physiological inhibitor of Gelatinases A and B respectively. The aim of this review is to determine the current understanding of the clinical and prognostic role of Metalloproteinases-2 and -9 and their inhibitors in the course of breast cancer and liver diseases. Forty-one articles were selected from PubMed by entering the following keywords: liver diseases, breast cancer, MMP-2, TIMP-2; all articles were read and notes were made regarding the number of enrolled patients, pathology, measures, results and these data were used to write this review. Over-expression of both gelatinases is associated with the relapse of disease, metastasis, shorter overall survival in breast cancer and hepatocellular carcinoma and invasion and progression to tumors in chronic liver diseases, and MMPs/TIMPs ratio could be useful in the follow-up of these patients.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Gelatinases
Gelatinase A
Breast Neoplasms
Disease
Matrix metalloproteinase
Biochemistry
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Animals
Humans
Medicine
business.industry
Liver Neoplasms
Tissue Inhibitor of Metalloproteinases
Cell Biology
Prognosis
medicine.disease
030104 developmental biology
Matrix Metalloproteinase 9
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Immunology
Matrix Metalloproteinase 2
business
Breast carcinoma
Subjects
Details
- ISSN :
- 13572725
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- The International Journal of Biochemistry & Cell Biology
- Accession number :
- edsair.doi.dedup.....a540b55d190dde56b73187ad647b01bd