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MRI Detection of Intratumoral Fat in Hepatocellular Carcinoma: Potential Biomarker for a More Favorable Prognosis
- Source :
- American Journal of Roentgenology. 199:1018-1025
- Publication Year :
- 2012
- Publisher :
- American Roentgen Ray Society, 2012.
-
Abstract
- The purpose of this study was to determine whether the presence of intratumoral fat in hepatocellular carcinoma (HCC) could serve as an imaging biomarker to predict a favorable prognosis.After a search of the radiology and pathology databases from January 2002 to December 2010, a cohort of patients with fat-containing HCC imaged by chemical-shift MRI techniques was matched with a cohort of patients with nonfat-containing HCC for TNM stage and type of subsequent treatment. The number and type of tumor progression, time to tumor progression (TTP), and overall survival (OS) were determined for each cohort.There were 46 patients included in each cohort. Tumor progression was more prevalent in the non-fat-containing HCC cohort (30 patients, 65.2%) compared with the fat-containing HCC cohort (16 patients, 34.7%; p = 0.001). Distant metastasis occurred more commonly in the non-fat-containing HCC cohort (10 patient, 21.7%) compared with the fat-containing HCC cohort (two patients, 4.3%; p = 0.039). The median TTP was significantly longer in the fat-containing HCC group (52 months) compared with the non-fat-containing HCC group (27 months; p = 0.037). The significantly longer TTP was primarily observed in the locoregional treatment subgroup (p = 0.028). No statistical significance in OS and subanalysis by treatment was observed (p = 0.63-0.81).Fat-containing HCC, imaged on an MRI unit, may predict a more favorable prognosis compared with nonfat-containing HCC.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Carcinoma, Hepatocellular
Imaging biomarker
Contrast Media
Favorable prognosis
Imaging, Three-Dimensional
Internal medicine
Image Interpretation, Computer-Assisted
medicine
Overall survival
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
neoplasms
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Analysis of Variance
business.industry
Liver Neoplasms
General Medicine
Middle Aged
Prognosis
medicine.disease
Magnetic Resonance Imaging
digestive system diseases
Survival Rate
Adipose Tissue
Tumor progression
Potential biomarkers
Hepatocellular carcinoma
Cohort
Disease Progression
Female
Tomography, X-Ray Computed
business
Biomarkers
Subjects
Details
- ISSN :
- 15463141 and 0361803X
- Volume :
- 199
- Database :
- OpenAIRE
- Journal :
- American Journal of Roentgenology
- Accession number :
- edsair.doi.dedup.....a53f287de22e5b10c7daf8f852708c03