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Targeted delivery of intranasally administered nanoparticles-mediated neuroprotective peptide NR2B9c to brain and neuron for treatment of ischemic stroke
- Source :
- Nanomedicine : nanotechnology, biology, and medicine. 18
- Publication Year :
- 2018
-
Abstract
- The lack of effective therapies mandates the development of new treatment strategies for ischemic stroke. The NR2B9c peptide can prevent N-Methyl-D-aspartate receptor (NMDAR)-mediated neurotoxicity induced by ischemia without affecting essential NMDAR activity and brings hope for stroke therapy. However, it is very difficult for NR2B9c to cross by itself the blood-brain barrier (BBB) and the neuron membrane. To provide a suitable delivery for unleashing the therapeutic potential of NR2B9c, in consideration of a high affinity of wheat germ agglutinin (WGA) for WGA receptors abundantly present on olfactory epithelium and neuronal surface, we developed WGA-modified nanoparticles carrying NR2B9c (NR2B9c-WGA-NPs). Following intranasal administration, NR2B9c-WGA-NPs are able to bypass the BBB and effectively transport NR2B9c into the brain and neuron, and therefore can protect neurons against excitotoxicity, reduce ischemic brain injury in rats and ameliorate their neurological function deficits. The intranasal administration of NR2B9c-WGA-NPs may serve as a practical stroke therapy.
- Subjects :
- Wheat Germ Agglutinins
Biomedical Engineering
Excitotoxicity
Ischemia
Pharmaceutical Science
Medicine (miscellaneous)
Bioengineering
02 engineering and technology
Pharmacology
medicine.disease_cause
Neuroprotection
Brain Ischemia
03 medical and health sciences
Drug Delivery Systems
medicine
Animals
Humans
General Materials Science
Tissue Distribution
Stroke
Administration, Intranasal
030304 developmental biology
Neurons
0303 health sciences
business.industry
Neurotoxicity
Brain
021001 nanoscience & nanotechnology
medicine.disease
Wheat germ agglutinin
Rats
medicine.anatomical_structure
Neuroprotective Agents
nervous system
Molecular Medicine
Nanoparticles
Nasal administration
Neuron
0210 nano-technology
business
Peptides
Subjects
Details
- ISSN :
- 15499642
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Accession number :
- edsair.doi.dedup.....a53bcd28026cf383ddd6d29d02c9c967