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Formation of highly stable multinuclear AgnSnclusters in zinc fingers disrupts their structure and function
- Source :
- Chemical Communications, Chemical Communications, Royal Society of Chemistry, 2020, 56 (9), pp.1329-1332. ⟨10.1039/c9cc09418k⟩, Chemical Communications, 2020, 56 (9), pp.1329-1332. ⟨10.1039/c9cc09418k⟩
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- International audience; Silver (Ag(I)) binding to consensus zinc fingers (ZFs) causes Zn(II) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(I)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.
- Subjects :
- Zinc finger
chemistry.chemical_classification
0303 health sciences
Conformational change
Chemistry
Biomolecule
Metals and Alloys
General Chemistry
010402 general chemistry
01 natural sciences
Catalysis
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Structure and function
03 medical and health sciences
Crystallography
Materials Chemistry
Ceramics and Composites
Cluster (physics)
Transcriptional regulation
[CHIM]Chemical Sciences
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
030304 developmental biology
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....a52debd28ecf58c02204f76c0c2d9fda
- Full Text :
- https://doi.org/10.1039/c9cc09418k