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Cross-linked hyaluronic acid filler hydrolysis with hyaluronidase: Different settings to reproduce different clinical scenarios
- Publication Year :
- 2020
-
Abstract
- Skin necrosis is the most severe complication arising from hyaluronic acid (HA) injection. To avoid skin necrosis, hyaluronidase should be injected along the course of the involved artery, to allow blood flow restoration. We evaluated the ability of hyaluronidase to degrade a HA filler in two simulated clinical situations-a compression case and an embolization case-to identify differences in the hyaluronidase injection. In the compression case, a bolus of HA filler was directly soaked in hyaluronidase solution; in the embolization case, a vein harvested from a living patient was filled with the same HA filler and then soaked in hyaluronidase. We then evaluated the quantity of HA remaining after 2 hr. While we found hydrolysis of HA in both cases, in the compression case, we detected almost complete hydrolysis, whereas in the embolization case we observed a reduction of the 60%. Our results support the hypothesis that vessel compression can be resolved with only one injection of hyaluronidase, while in the case of vascular embolization, repeated perivascular injections should be performed owing to the reduction of hyaluronidase activity.
- Subjects :
- medicine.medical_specialty
Necrosis
Injections, Subcutaneous
medicine.medical_treatment
Urology
Hyaluronoglucosaminidase
hyaluronidase
Dermatology
embolism
030207 dermatology & venereal diseases
03 medical and health sciences
Hydrolysis
chemistry.chemical_compound
0302 clinical medicine
Bolus (medicine)
Hyaluronidase
Dermal Fillers
Hyaluronic acid
hyaluronic acid
medicine
Humans
Embolization
Severe complication
business.industry
impending necrosis
vessel compression
impending necrosi
General Medicine
medicine.disease
Embolism
chemistry
030220 oncology & carcinogenesis
medicine.symptom
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....a50b0e152aa5383a639d09d809935944