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Irritable bowel syndrome, the microbiota and the gut-brain axis
- Source :
- Gut Microbes. 7:365-383
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
media_common.quotation_subject
Gut–brain axis
Review
Bioinformatics
digestive system
Microbiology
Gastroenterology
Irritable Bowel Syndrome
03 medical and health sciences
0302 clinical medicine
Functional gastrointestinal disorder
Internal medicine
medicine
Animals
Humans
Central function
Irritable bowel syndrome
media_common
Gut motility
business.industry
digestive, oral, and skin physiology
Gastrointestinal Microbiome
Brain
Appetite
medicine.disease
Gastrointestinal Tract
Autonomic nervous system
030104 developmental biology
Infectious Diseases
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 19490984 and 19490976
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Gut Microbes
- Accession number :
- edsair.doi.dedup.....a509e93ec4513c80245e811ce4cabdef