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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
- Source :
- Nature reviews / Neuroscience 22(11), 1903-1912 (2019). doi:10.1038/s41593-019-0501-5, Nature neuroscience
- Publication Year :
- 2019
- Publisher :
- Nature Publ. Group62203, 2019.
-
Abstract
- Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. It was demonstrated that most circRNA-AD associations are independent of changes in cognate linear messenger RNA expression or estimated brain cell-type proportions. Evidence was provided for circRNA expression changes occurring early in presymptomatic AD and in autosomal dominant AD. It was also observed that AD-associated circRNAs co-expressed with known AD genes. Finally, potential microRNA-binding sites were identified in AD-associated circRNAs for miRNAs predicted to target AD genes. Together, these results highlight the importance of analyzing non-linear RNAs and support future studies exploring the potential roles of circRNAs in AD pathogenesis.
- Subjects :
- 0301 basic medicine
metabolism [Parietal Lobe]
Posterior parietal cortex
Biology
Severity of Illness Index
Article
Pathogenesis
03 medical and health sciences
pathology [Alzheimer Disease]
0302 clinical medicine
Atlases as Topic
Alzheimer Disease
Circular RNA
metabolism [MicroRNAs]
Parietal Lobe
ddc:570
microRNA
medicine
Dementia
Humans
RNA, Messenger
Gene
Messenger RNA
biosynthesis [RNA, Messenger]
Sequence Analysis, RNA
General Neuroscience
Gene Expression Profiling
diagnosis [Alzheimer Disease]
RNA, Circular
medicine.disease
biosynthesis [RNA, Circular]
MicroRNAs
030104 developmental biology
Case-Control Studies
Alzheimer's disease
Neuroscience
030217 neurology & neurosurgery
metabolism [Alzheimer Disease]
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nature reviews / Neuroscience 22(11), 1903-1912 (2019). doi:10.1038/s41593-019-0501-5, Nature neuroscience
- Accession number :
- edsair.doi.dedup.....a4f90a711afa74811cc5b8c04b1a3813