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Efficacy of a hydrogel spacer in three-dimensional conformal radiation therapy for prostate cancer
- Source :
- Japanese journal of clinical oncology. 50(3)
- Publication Year :
- 2019
-
Abstract
- Objectives We aimed to compare the dose constraints fulfillment rate of the three-dimensional conformal radiotherapy treatment plan before and after a hydrogel spacer insertion. Methods The planning computed tomography scans of 39 patients who received stereotactic body radiotherapy for prostate cancer were used. All patients inserted a hydrogel spacer and underwent computed tomography scans before and after spacer insertion. The three-dimensional conformal radiotherapy plans according to NCCN classification, low-, intermediate- and high-risk, were made for each patient. Clinical target volume included prostate and seminal vesicle 2 cm for high risk, prostate and seminal vesicle 1 cm for intermediate risk and prostate only for low risk. Three-dimensional conformal radiotherapy including a seven-field conformal technique with 76 Gy in 38 fractions. Dose constraints for rectum and bladder were V70 Gy ≤ 15%, V65 Gy ≤ 30% and V40 Gy ≤ 60%. Results Among 39 patients, 35 (90%), 19 (49%) and 13 (33%) and 38 (97%), 38 (97%) and 34 (87%) patients before and after the spacer insertion fulfilled rectum dose constraints for low-, intermediate- and high-risk plans, respectively. A hydrogel spacer significantly reduced rectum dose and improved the rectum dose constraints fulfillment rate in intermediate (P Conclusions A hydrogel spacer reduced rectum dose and improved the dose constraints fulfillment rate in three-dimensional conformal radiotherapy plan. Although IMRT is the standard treatment, 3D-CRT using a hydrogel spacer may be a treatment option.
- Subjects :
- Male
Cancer Research
medicine.medical_treatment
Planning target volume
Conformal radiation therapy
Rectum
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Prostate
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Urinary bladder
business.industry
Standard treatment
Prostatic Neoplasms
Hydrogels
Radiotherapy Dosage
General Medicine
medicine.disease
Radiation therapy
medicine.anatomical_structure
Oncology
Equipment and Supplies
030220 oncology & carcinogenesis
Radiotherapy, Conformal
Nuclear medicine
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 14653621
- Volume :
- 50
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Japanese journal of clinical oncology
- Accession number :
- edsair.doi.dedup.....a4f25694cd748705d5af5ccbb289a3fe