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Ki-67 Labeling Index in Breast Cancer
- Source :
- Tumori Journal. 75:557-562
- Publication Year :
- 1989
- Publisher :
- SAGE Publications, 1989.
-
Abstract
- Measurements of cell cycle kinetics have been found to correlate with the clinical course of patients with breast cancer. However, the thymidine labeling index and more rapid methods like flow cytometry remain complicated and costly. We assessed cell proliferation of 67 breast carcinomas by an immunoperoxidase procedure using a monoclonal antibody, Ki-67, which reacts with a nuclear antigen in proliferating cells. The percentage of Ki-67 positive cells ranged from 2% to 70 %. Tumors with high mitotic rate, high nuclear grade, high histologic grade, and negative estrogen receptors had statistically higher Ki-67 labeling rates. We found no significant differences between the Ki-67 labeling rate and other clinical (age at diagnosis, menopausal status) or pathologic (necrosis, fibrosis, vascular invasion, lymphatic invasion, cellular reaction, tumor size, lymph node metastases) features assessed. These results parallel previously reported data, and confirm that this immunohistochemical staining of breast carcinoma by Ki-67 monoclonal antibody can be considered a rapid and convenient method for assessing cell cycle kinetics. However, further studies, evaluating the correlation between Ki-67 labeling rate and prognosis are needed to better define the real usefulness of this analysis in clinical practice.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Mitotic index
Estrogen receptor
Breast Neoplasms
030218 nuclear medicine & medical imaging
Immunoenzyme Techniques
Necrosis
03 medical and health sciences
0302 clinical medicine
Breast cancer
Mitotic Index
Humans
Medicine
Lymph node
Neoplasm Staging
biology
business.industry
Carcinoma
Cell Cycle
Antibodies, Monoclonal
General Medicine
Middle Aged
medicine.disease
Fibrosis
medicine.anatomical_structure
Receptors, Estrogen
Oncology
Lymphatic Metastasis
030220 oncology & carcinogenesis
Ki-67
Cell Cycle Kinetics
Monoclonal
biology.protein
Female
business
Breast carcinoma
Subjects
Details
- ISSN :
- 20382529 and 03008916
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Tumori Journal
- Accession number :
- edsair.doi.dedup.....a4ee12d9f902443664e1dfb77b9be172