Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

Authors :: Simona De Marino
Maria Valeria D'Auria
Angela Zampella
Carmen Festa
Thierry Cresteil
Cécile Debitus
Institut de Chimie des Substances Naturelles (ICSN)
Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
De Marino, S.
Festa, Carmen
D'Auria, M. V.
Cresteil, T.
Debitus, C.
Zampella, A.
Source :: Marine Drugs, Marine Drugs (1660-3397) (Mdpi Ag), 2011-06, Vol. 9, N. 6, P. 1133-1141, Marine Drugs; Volume 9; Issue 6; Pages: 1133-1141, Marine drugs, Marine drugs, MDPI, 2011, 9 (6), pp.1133-41. ⟨10.3390/md9061133⟩, Marine Drugs, Vol 9, Iss 6, Pp 1133-1141 (2011)
Publication Year :: 2011
Publisher :: MDPI AG, 2011.
Abstract: International audience; In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.